249. Doctors still know little about how the Listeria bacterium is spread and why the disease it causes, listeriosis, afflicts some people in a contaminated area though it spares many others. (A) though it spares (B) where it spares (C) despite sparing (D) when sparing (E) while sparing E afflicts的主语是listeriosis吗?中间为什么用逗号分开呢?这里while是什么用法?while不是应该做连词使用吗?我没有语法书,麻烦大家跟我讲讲while的用法吧,多谢了。